proviral dna造句

• Engagement of CD81 lowers the signaling threshold required to trigger T-Cell \ CD3 mediated proviral DNA in CD4 + T cells.
• Although much less commonly available, nucleic acid testing ( e . g ., viral RNA or proviral DNA amplification method ) can also help diagnosis in certain situations.
• The second replication process occurs when host cellular DNA polymerase replicates the integrated viral DNA . Lastly, RNA polymerase II transcribes the proviral DNA into RNA, which will be packed into virions.
• The deamination activity ultimately results in G?! A hypermutations at  hot spots of the proviral DNA . Such hypermutation ultimately destroys the coding and replicative capacity of the virus, resulting in many nonviable virions.
• A retrovirus is endogenous to its host once the proviral DNA is inserted into the chromosomal DNA . As a result, mice with endogenous MMTV have the virus s DNA in every cell of its body, as the virus is present in the DNA of the sperm or egg cell from which the animal is conceived.
• In a study published by the Proceedings of the National Academy of Sciences ( PNAS ), Dr . Khalili and colleagues detail how they created molecular tools to delete the HIV-1 proviral DNA . When deployed, a combination of DNA-snipping enzyme called a nuclease and targeting strand of RNA called a guide RNA ( gRNA ) hunt down the viral genome and excise the HIV-1 DNA . From there, the cell's own gene repair machinery takes over, soldering the loose ends of the genome back together  resulting in virus-free cells.